This is a part of the historical and cultural roots of North America, where many societies flourished for more than 3,000 years, before the Spanish started to colonize the region, and areas. Unfortunately, along with the hordes of men, horses, and weapons, the Spaniards also brought all kinds of germs with them, that these people were not used to, which made them sick, and even die in numbers.
The Mesoamerica changed in two big ways, starting with the
primary urban generation, which to my understanding, was one of the very first
places in cultural history to transform from a place, or village, into a city.
The other change was the cultural formation of the New World, which was a
combination of the indigenous Mesoamerican people, like the Mayans, Incans, and
Aztecs, and their descendants, with European, African and Asian settlers.